Natural naphthoquinones isolated from Lithospermum erythrorhizon suppress dextran sulfate sodium-induced murine experimental colitis
W. X. Sun, H. W. Han, Z. Y. Wang, Z. L. Wen, M. K. Yang, Y. S. Wang, J. Y. Fu, L. Feng, X. H. Xu, T. M. Yin, X. M. Wang, G. H. Lu, J. L. Qi, H. Y. Lin, Y.- H. Yang
This study shows that shikonin and its derivatives reduce inflammation in DSS-induced colitis by inhibiting NLRP3 inflammasome and NF-κB pathways.
bioRxiv · Nov 4, 2019 · PreprintBiochemistry