bioRxivBiophysics
Activation and desensitization mechanism of AMPA receptor-TARP complex by cryo-EM
S. Chen, Y. Zhao, Y. S. Wang, M. Shekhar, E. Tajkhorshid, E. Gouaux
Abstract
Summary Summary Structure determination Agonists expand LBD gating... Activation by full and... Architecture of the ion... Ion-permeation profile of the... Asymmetric water/ion accessible... TARP modulation of receptor... TARP restricts LBD rearrangement... TARP modulation of AMPA... Materials and methods AUTHOR CONTRIBUTIONS AUTHOR INFORMATION References AMPA receptors mediate the majority of fast excitatory neurotransmission in the mammalian brain and transduce the binding of presynaptically released glutamate to the opening of a transmembrane cation channel. Within the postsynaptic density, however, AMPA receptors coassemble with transmembran ...
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