Visualizing looping of two endogenous genomic loci using synthetic zinc-finger proteins with anti-FLAG and anti-HA frankenbodies in living cells
Y. Liu, N. Zhao, M. T. Kanemaki, Y. Yamamoto, Y. Sadamura, Y. Ito, M. Tokunaga, T. J. Stasevich, H. Kimura
The paper introduces a method to visualize two endogenous chromatin loci in living cells using synthetic zinc-finger proteins and frankenbodies, revealing their dynamic association and separation upon cohesin disruption.
bioRxiv · Jun 16, 2021Cell Biology