M. Tokunaga

Viral antigen mismatch affects antiviral T-cell response and may impair immunotherapeutic efficacy against ATL

This study shows that mismatch between viral antigen epitopes and T-cell responses in HTLV-1 infection may reduce immunotherapy effectiveness against ATL.

Importin-7-dependent nuclear localization of the Flavivirus core protein is required for infectious virus production.

This study identifies importin-7 as a nuclear carrier for Flaviviridae core proteins and shows its requirement for infectious virus production.

Slitflow: a Python framework for single-molecule dynamics and localization analysis

Slitflow is a Python framework for single-molecule dynamics and localization analysis, offering a flexible workflow for image processing, dynamics analysis, and figure creation.

AT-hook DNA-binding motif-containing protein one knockdown downregulates EWS-FLI1 transcriptional activity in Ewings sarcoma cells

The paper identifies AHDC1 as a protein interacting with EWS-FLI1 in Ewing's sarcoma and shows its knockdown reduces cell growth and transcriptional activity.

Retrovirus-induced leukemia - hijack of T-cell activation mechanisms revealed by single-cell analysis

This study uses single-cell RNA-Seq and TCR-Seq to show HTLV-1-infected T-cells transition into highly activated ATL cells with Treg signatures and upregulated HLA class II, enabling immune evasion.

Visualizing looping of two endogenous genomic loci using synthetic zinc-finger proteins with anti-FLAG and anti-HA frankenbodies in living cells

The paper introduces a method to visualize two endogenous chromatin loci in living cells using synthetic zinc-finger proteins and frankenbodies, revealing their dynamic association and separation upon cohesin disruption.

Visualizing transcription sites in living cells using a genetically encoded probe specific for the elongating form of RNA polymerase II

The paper develops a genetically encoded probe to detect elongating RNA polymerase II in living cells and shows its foci move more dynamically than chromatin domains.

USP15 participates in HCV propagation through the regulation of viral RNA translation and lipid droplet formation

This study identifies USP15 as a host factor for HCV propagation, showing it regulates viral RNA translation and lipid droplet formation in hepatic cells.