Y. Tesfagiorgis

Systemic administration of anti-CD20 indirectly reduces B cells in the inflamed meninges in a chronic model of central nervous system autoimmunity

This study shows that anti-CD20 therapy reduces B cells in the inflamed meninges indirectly through peripheral B cell depletion and turnover, leading to reduced demyelination and increased T cell recruitment to meninges.

Autoreactive T cells preferentially drive differentiation of non-responsive memory B cells at the expense of germinal center maintenance.

The paper compares B cell fate outcomes in responses to autoantigen MOG and foreign antigen NPOVA, showing that autoreactive T cells drive memory B cell differentiation at the expense of germinal center maintenance.