S. M. Kerfoot

This study shows that deleting Pannexin 1 in a melanoma mouse model increases CD8+ T cell infiltration without affecting tumor growth or survival.

The paper examines T-B cell interactions in response to self-antigen MOG and foreign antigen NP-OVA, finding lower quality interactions with MOG that may represent natural checkpoints to limit autoimmune responses.

This study shows that staphylococcal superantigens increase S. aureus bloodstream infection severity by inducing high IFNγ production, which impairs macrophage function and allows bacterial survival.

This study shows that anti-CD20 therapy reduces B cells in the inflamed meninges indirectly through peripheral B cell depletion and turnover, leading to reduced demyelination and increased T cell recruitment to meninges.

The paper compares B cell fate outcomes in responses to autoantigen MOG and foreign antigen NPOVA, showing that autoreactive T cells drive memory B cell differentiation at the expense of germinal center maintenance.