H. C. Craig

Pre-Germinal Center Interactions with T Cells are Natural Checkpoints to Limit Autoimmune B Cell Responses

The paper examines T-B cell interactions in response to self-antigen MOG and foreign antigen NP-OVA, finding lower quality interactions with MOG that may represent natural checkpoints to limit autoimmune responses.

The Streptococcus pyogenes hyaluronic acid capsule promotes experimental nasal and skin infection by preventing neutrophil-mediated clearance

This study shows that the hyaluronic acid capsule of Streptococcus pyogenes protects against neutrophil-mediated killing during nasal and skin infections, increasing bacterial burden.

Superantigens promote Staphylococcus aureus bloodstream infection by eliciting pathogenic interferon-gamma (IFNγ) production that subverts macrophage function

This study shows that staphylococcal superantigens increase S. aureus bloodstream infection severity by inducing high IFNγ production, which impairs macrophage function and allows bacterial survival.

Systemic administration of anti-CD20 indirectly reduces B cells in the inflamed meninges in a chronic model of central nervous system autoimmunity

This study shows that anti-CD20 therapy reduces B cells in the inflamed meninges indirectly through peripheral B cell depletion and turnover, leading to reduced demyelination and increased T cell recruitment to meninges.

Autoreactive T cells preferentially drive differentiation of non-responsive memory B cells at the expense of germinal center maintenance.

The paper compares B cell fate outcomes in responses to autoantigen MOG and foreign antigen NPOVA, showing that autoreactive T cells drive memory B cell differentiation at the expense of germinal center maintenance.