Galectin-8 is a major ligand of LILRB4 prompting MDSC functions in the tumor microenvironment
Y. Wang, Y.-F. Sun, S. Deng, T. Song, Y. Wang, J. Xu
This study identifies Galectin-8 as a functional ligand of LILRB4 that promotes MDSC expansion and tumor growth, suggesting its blockade as a potential immunotherapy strategy.
bioRxiv · Jul 27, 2022 · PreprintImmunology