HDAC5 tunes effector competence in differentiated human CD8+ T cells through an ACTL6A-IRF4 axis
Megan Borregard, Yandong Zhang, Yizhen Jin, Pascal Devant, Cezary Ciszewski, Sonia S. Kupfer, Alexander Marson, Hening Lin, Bana Jabrì
This study identifies HDAC5 as a regulator of effector competence in human CD8+ T cells, showing it modulates cytokine responses and TCR activation through an ACTL6A-IRF4 axis.
bioRxiv · Oct 23, 2026 · PreprintImmunology