Sonia S. Kupfer

This study identifies HDAC5 as a regulator of effector competence in human CD8+ T cells, showing it modulates cytokine responses and TCR activation through an ACTL6A-IRF4 axis.

LBV-Seq enables de novo reconstruction of DNA and RNA viral genomes from low-input samples, achieving broad genome coverage and resolving strains and gene-level variation.

The paper identifies an ancestry-related regulatory variant of POLB associated with 1,25D responses in colonic organoids from African- and European-Americans.