Author

Yizhen Jin

University of ChicagoORCID 0000-0001-8784-721XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:bacteria (other)· 1 Approach:deep learning· 1 Organism:human· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Hening LiniD· 3 shared Alexander MarsoniD· 1 shared Bana JabrìiD· 1 shared Cezary CiszewskiiD· 1 shared Kewen PengiD· 1 shared Megan BorregardiD· 1 shared Mikail E. AbbasoviD· 1 shared Pascal DevantiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersBiochemistry

Hening LinORCID

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3 papers

Recent·Most cited

ImmunologybioRxivPreprintOct 23, 2026

HDAC5 tunes effector competence in differentiated human CD8+ T cells through an ACTL6A-IRF4 axis

Megan Borregard, Yandong Zhang, Yizhen Jin…·Bana Jabrì

This study identifies HDAC5 as a regulator of effector competence in human CD8+ T cells, showing it modulates cytokine responses and TCR activation through an ACTL6A-IRF4 axis.

DOI 10.64898/2026.10.18.759972

humanexperimental assay

𝕏 PostBluesky

BiochemistryACS Chemical BiologyPeer-reviewedApr 17, 2026

A High-throughput Fluorescence Polarization Assay for Screening Sirtuin Inhibitors

Kewen Peng, Suryadeep Chakraborty, Yizhen Jin, Hening Lin

The paper develops a high-throughput fluorescence polarization assay to screen SIRT1-3 inhibitors, showing improved efficiency and performance compared to existing methods.

DOI 10.1021/acschembio.6c00205

experimental assaydrug response / drug discovery

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BiochemistryCell chemical biologyPeer-reviewedFeb 27, 2025

Phenotypic screening of covalent compound libraries identifies chloromethyl ketone antibiotics and MiaA as a new target

Yizhen Jin, Sadhan Jana, Mikail E. Abbasov, Hening Lin

12 citationstop 4%

bacteria (other)proteomics

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