Histone H3 serotonylation dynamics in dorsal raphe nucleus contribute to stress- and antidepressant-mediated gene expression and behavior
Amni Al-Kachak, Sasha L. Fulton, Giuseppina Di Salvo, Jennifer C Chan, Lorna A. Farrelly, Ashley E. Lepack, Ryan M. Bastle, Lingchun Kong, Flurin Cathomas, Emily L. Newman, Caroline Ménard, Aarthi Ramakrishnan, Polina Safovich, Yang Lyu, Herbert E. Covington, , Ian S. Maze
The paper investigates how serotonin modifies histone H3K4me3Q5ser dynamics in the dorsal raphe nucleus under stress and antidepressant exposure, showing its role in gene expression and behavior.
bioRxiv · May 4, 2023 · PreprintNeuroscience