Author

Amni Al-Kachak

Icahn School of Medicine at Mount SinaiORCID 0000-0002-3155-8520Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Aarthi RamakrishnaniD· 2 shared Ashley E. LepackiD· 2 shared Carol A. TammingaiD· 2 shared Flurin CathomasiD· 2 shared Giuseppina Di SalvoiD· 2 shared Ian S. MazeiD· 2 shared Kelly Gleason· 2 shared Li SheniD· 2 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersNeuroscience

Aarthi RamakrishnanORCID

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2 papers

Recent·Most cited

ZBTB7A regulates MDD-specific chromatin signatures and astrocyte-mediated stress vulnerability in orbitofrontal cortex

Sasha L. Fulton, Jaroslav M. Bendl, Giuseppina Di Salvo, John F. Fullard, Amni Al-Kachak, Ashley E. Lepack, Andrew F. Stewart, Sumnima Singh, Wolfram C. Poller, Ryan M. Bastle, Mads E. Hauberg, Amanda K. Fakira, Vishwendra Patel, Min Chen, Romain Durand-de Cuttoli, , Ian S. Maze

The paper identifies ZBTB7A as a key regulator of MDD-specific chromatin signatures and astrocyte-mediated stress vulnerability in the orbitofrontal cortex.

Neuron · Jun 13, 2025Peer-reviewedNeuroscience

Histone H3 serotonylation dynamics in dorsal raphe nucleus contribute to stress- and antidepressant-mediated gene expression and behavior

Amni Al-Kachak, Sasha L. Fulton, Giuseppina Di Salvo, Jennifer C Chan, Lorna A. Farrelly, Ashley E. Lepack, Ryan M. Bastle, Lingchun Kong, Flurin Cathomas, Emily L. Newman, Caroline Ménard, Aarthi Ramakrishnan, Polina Safovich, Yang Lyu, Herbert E. Covington, , Ian S. Maze

The paper investigates how serotonin modifies histone H3K4me3Q5ser dynamics in the dorsal raphe nucleus under stress and antidepressant exposure, showing its role in gene expression and behavior.

bioRxiv · May 4, 2023 · PreprintNeuroscience