Ciliated cells promote high infectious potential of influenza A virus through the efficient intracellular activation of hemagglutinin
Zijian Guo, Victoria S. Banas, Yuanyuan He, Elizabeth A. Weiland, Jian Xu, Yangjie Tan, Zhaoxi Xiao, Steven L. Brody, Adrianus C. M. Boon, James W. Janetka, Michael D. Vahey
The paper shows ciliated airway cells activate influenza HA more efficiently than non-ciliated cells, and HA activation occurs intracellularly in the Golgi, affecting antiviral protease inhibitor efficacy.
Journal of Virology · Aug 29, 2025Peer-reviewedMicrobiology