Jian Xu

Hidden genetic diversity in 320 nearly-complete East Asian genome assemblies

The paper presents 320 nearly-complete East Asian genome assemblies, revealing new genetic diversity and structural variations not present in existing global pangenomes.

Metabolism-driven, high-efficiency mining of ethanol-tolerant microorganisms from pit mud microbiota using Raman flow cytometry

This paper develops a Raman flow cytometry-based method to efficiently screen and isolate ethanol-tolerant microorganisms from pit mud microbiota, achieving higher throughput and accuracy than conventional methods.

Ciliated cells promote high infectious potential of influenza A virus through the efficient intracellular activation of hemagglutinin

The paper shows ciliated airway cells activate influenza HA more efficiently than non-ciliated cells, and HA activation occurs intracellularly in the Golgi, affecting antiviral protease inhibitor efficacy.

TOMM40-APOE chimera linking Alzheimer's highest risk genes: a new pathway for mitochondria regulation and APOE4 pathogenesis

The paper identifies a TOMM40-APOE chimera (T9A2) that links APOE4 to mitochondrial dysfunction and oxidative stress, suggesting a new pathway in Alzheimer's disease pathogenesis.

Three-dimensional molecular architecture of mouse organogenesis

This study creates a 3D spatial transcriptome atlas of mouse embryos at embryonic day 13.5, integrating with single-cell data to reveal molecular regulation of organ development.

Sexual dimorphism in a neuronal mechanism of spinal hyperexcitability across rodent and human models of pathological pain

The paper identifies a sex-specific neuronal mechanism of spinal hyperexcitability in pain models, showing differences in BDNF signaling between male and female rodents and humans.

Inhibition of Striatal-Enriched Protein Tyrosine Phosphatase (STEP) Activity Reverses Behavioral Deficits in a Rodent Model of Autism.

This study investigates the role of STEP in a VPA-induced ASD mouse model and finds that STEP inhibition reverses behavioral deficits.