Author

Yuanyuan He

Washington University in St. LouisORCID 0000-0002-1254-318XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 1 Assay:fluorescence / live-cell microscopy· 1 Organism:human· 1

Frequent Co-Authors

Michael D. VaheyiD· 3 shared Zijian GuoiD· 3 shared Adrianus C. M. BooniD· 1 shared Ananya BenegaliD· 1 shared Elizabeth A. Weiland· 1 shared Giselle Groff· 1 shared James W. JanetkaiD· 1 shared Jian Xu· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersBiophysics

Michael D. VaheyORCID

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3 papers

Recent·Most cited

BiophysicsPLoS PathogensPeer-reviewedFeb 5, 2026

Antigen flexibility supports the avidity of hemagglutinin-specific antibodies at low antigen densities

Ananya Benegal, Yuanyuan He, Katilyn Ho…·Michael D. Vahey

The paper measures antibody avidity to influenza HA at varying densities and identifies HA flexibility as a factor influencing antibody binding.

2 citations

fluorescence / live-cell microscopyexperimental assay

𝕏 PostBluesky

MicrobiologyJournal of VirologyPeer-reviewedAug 29, 2025

Ciliated cells promote high infectious potential of influenza A virus through the efficient intracellular activation of hemagglutinin

Zijian Guo, Victoria S. Banas, Yuanyuan He…·Michael D. Vahey

The paper shows ciliated airway cells activate influenza HA more efficiently than non-ciliated cells, and HA activation occurs intracellularly in the Golgi, affecting antiviral protease inhibitor efficacy.

9 citationstop 3%

humanbulk RNA-seq

𝕏 PostBluesky

ImmunologyCell ReportsPeer-reviewedJul 1, 2025

Modulation of B cell receptor activation by antibody competition

Yuanyuan He, Zijian Guo, Michael D. Vahey

This study investigates how antibodies affect B cell receptor access to viral epitopes, finding that proximity, affinity, and valency influence epitope masking.

3 citations

experimental assayhost-pathogen & immune response

𝕏 PostBluesky