Adrianus C. M. Boon

This study characterizes the antigenic properties of SARS-CoV-2 variants BA.3.2.1 and BA.3.2.2 in three animal models and finds they are antigenically divergent from existing variants with lower homologous serum titers.

This study identifies RNA secondary structures in influenza A virus gene segments and shows that mutations in packaging signal structures reduce viral replication.

The paper develops and tests new inhibitors of TMPRSS2 to block replication of SARS-CoV-2 and H1N1 influenza virus.

Booster SARS-CoV-2 mRNA vaccine recruits and broadens GC B cell responses targeting a highly conserved site on receptor binding domain of spike glycoprotein.

This study shows molnupiravir reduces BRBV infection and disease in mice by lowering virus burden and improving immune and clinical outcomes.

The paper shows ciliated airway cells activate influenza HA more efficiently than non-ciliated cells, and HA activation occurs intracellularly in the Golgi, affecting antiviral protease inhibitor efficacy.

The paper detects BRBV RNA in a coyote and identifies seropositive wildlife species in St. Louis, linking tick density and host composition to BRBV exposure.

This study uses barcoded SARS-CoV-2 viruses in Syrian hamsters to show that transmission bottleneck varies by exposure duration and route, with direct contact having the largest bottleneck.

This paper tests DDO268 as an adjuvant for an influenza A virus nucleoprotein mRNA vaccine in mice, showing enhanced immune responses and protection against viral challenge.

The paper identifies a single ANP32 locus in ticks that generates multiple variants supporting Thogoto virus polymerase activity, showing evolutionary plasticity across species.

This paper demonstrates that MM3122, a host cell serine protease inhibitor, effectively inhibits SARS-CoV-2 replication and reduces disease severity in mice, both prophylactically and therapeutically.

6-Thioguanine inhibits SARS-CoV-2 PLpro protease activity and replication in cell cultures at submicromolar concentrations.