Richard A.E. Edden

Metabolite Relaxation Times at 3T From Birth to 7 Years

The paper estimates age-related changes in metabolite relaxation times in pediatric thalamus using MRS and provides linear equations for age-specific correction.

Real-time AI integration for MR to detect artifacts and guide pulse sequence adaptations

This paper introduces an AI-integrated MRI pulse sequence that detects and adapts to out-of-voxel artifacts in real-time, improving data quality through gradient adjustments.

Age-related differences in neurometabolite concentrations during early infancy: A cross-sectional analysis of the HBCD Release 1.0

The paper analyzes age-related changes in neurometabolite concentrations in infants using 1H-MRS data from the HBCD study, finding significant increases in some metabolites and decreases in others.

Methylmalonic acid: a new target for Hadamard-edited MRS

This paper develops a Hadamard-edited MRS method to separate methylmalonic acid and lactate signals, demonstrating its effectiveness in vivo for MMAemia diagnosis.

Identifying out-of-voxel echoes in edited MRS with phase cycle inversion

The paper introduces a method to identify out-of-voxel signals in MRS by analyzing phase cycles, leading to improved suppression of artifacts through optimized gradients.

Gradient scheme optimization for PRESS-localized edited MRS using weighted pathway suppression

This paper optimizes a gradient scheme for PRESS-localized edited MRS to suppress out-of-voxel artifacts using a volume-based likelihood model and genetic algorithm.

Myo-inositol in the Dorsal Anterior Cingulate Cortex is Associated with Anxiety-to-Eat in Anorexia Nervosa

This study examines anxiety-to-eat in anorexia nervosa and finds lower myo-inositol levels in the dorsal anterior cingulate cortex associated with increased anxiety to eat high-energy density foods.

A data-driven algorithm to determine 1H-MRS basis set composition

This paper introduces a data-driven algorithm using AIC to determine the optimal basis set composition for 1H-MRS, showing improved accuracy in identifying metabolites.

Age dependency of neurometabolite T1 relaxation times

The paper measures metabolite T1 relaxation times in healthy adults across age groups and finds age-related decreases in several metabolites in specific brain regions.

"Surviving and Thriving": Evidence for Cortical GABA Stabilization in Cognitively-Intact Oldest-Old Adults

The paper examines age-related GABA level changes in cognitively-intact oldest-old adults, finding that GABA decline flattens after age 80, suggesting a link between GABAergic function and successful cognitive aging.

Metabolite T2 relaxation times decrease across the adult lifespan in a large multi-site cohort

The paper investigates age-related changes in metabolite T2 relaxation times across the adult lifespan in a multi-site cohort, finding significant declines in several metabolites with aging.

A Water Relaxation Atlas for Age and Region specific Metabolite Concentration Correction

This paper develops a water relaxation atlas to correct metabolite concentrations in MRS by integrating age and region-specific relaxation values into the analysis workflow.

Comparison of test-retest reproducibility of DESPOT and 3D-QALAS for water T1 and T2 mapping

This study compares the test-retest reproducibility of DESPOT and QALAS for T1 and T2 mapping in healthy volunteers, finding QALAS provides better reproducibility and reduced acquisition time.

Model-based frequency-and-phase correction of 1H MRS data with 2D linear-combination modeling.

This paper introduces a model-based frequency-and-phase correction method for 1H MRS data using 2D linear-combination modeling, showing improved performance over traditional approaches at low SNR.

Brain Glutathione and GABA+ levels in autistic children

This study found no significant differences in cerebral glutathione or GABA levels between autistic children and typically developing children, but found a positive correlation between GABA levels and ADHD inattention scores.

Impact of acquisition and modeling parameters on test-retest reproducibility of edited GABA+

This study evaluates how acquisition and modeling parameters affect test-retest reproducibility of GABA+ measurements using edited MRS, finding that model selection significantly impacts reproducibility.

Application of a 1H Brain MRS Benchmark Dataset to Deep Learning for Out-of-Voxel Artifacts

This paper introduces AGNOSTIC, a synthetic 1H MRS dataset for training deep learning models to detect and predict out-of-voxel echoes in brain MRS data.

The developmental trajectory of 1H-MRS brain metabolites from childhood to adulthood.

This study characterizes the developmental trajectories of brain metabolites measured by 1H-MRS from childhood to early adulthood, identifying non-linear changes in several metabolites and their associations with cognitive development.

Reduced brain glutathione levels during normal aging are associated with visuospatial memory

This study examines how brain glutathione levels change with age and their link to cognitive function in healthy adults, finding age-related declines in specific brain regions and sex differences in GSH dynamics.

Continuous automated analysis workflow for MRS studies

This paper introduces an automated MRS analysis workflow that reduces manual steps and integrates with neuroimaging standards, improving efficiency and scalability.

Meta-analysis and Open-source Database for In Vivo Brain Magnetic Resonance Spectroscopy Studies of Health and Disease

The paper conducts a meta-analysis of brain MRS studies to establish metabolite concentration ranges and relaxation rates for use in simulations and as references.

sLASER and PRESS Perform Similarly at Revealing Metabolite-Age Correlations

This study compares PRESS and sLASER for detecting metabolite-age correlations in brain regions, finding similar results despite technical differences.

Metabolite T1 relaxation times differ across the adult lifespan

The paper examines age-related changes in metabolite T1 relaxation times in brain regions using a cross-sectional dataset and finds significant decreases in white-matter-rich areas with age.

Neurometabolic timecourse of healthy aging

The paper investigates neurometabolic changes with age using MR spectroscopy in a cross-sectional cohort, finding age correlations for several metabolites but not others.

More than half of the variance in in-vivo 1H-MRS metabolite estimates is common to all metabolites

The paper shows that over half of the variance in 1H-MRS metabolite estimates is shared across all metabolites, with age and sex affecting this common variance.

The Value of Zero-filling in In Vivo MRS

This paper demonstrates that 2x zero-filling improves modeling accuracy in in vivo MRS data compared to no zero-filling, with no additional benefit from higher zero-filling.

Cohort-mean measured macromolecules lead to more robust linear-combination modeling than subject-specific or parameterized ones

This study compares metabolite estimation using different macromolecular modeling strategies and finds that cohort-mean measured MM basis functions yield more robust results than subject-specific or parameterized ones.

The interaction between endogenous GABA, functional connectivity and behavioral flexibility is critically altered with advanced age

This study examines age-related changes in endogenous GABA, functional connectivity, and behavioral flexibility during dynamic motor tasks.

Comparison of seven modelling algorithms for GABA-edited 1H-MRS

The paper compares seven algorithms for modelling GABA-edited 1H-MRS data from 222 subjects across 20 sites, finding moderate agreement and highlighting the need for standardized parameters.

Dysconnectivity between auditory-cognitive network associated with auditory GABA and glutamate levels in presbycusis patients

This study investigates dysconnectivity in the auditory-cognitive network and its relation to GABA and glutamate levels in presbycusis patients, linking neurochemical changes to cognitive impairment.