High-throughput diversification of protein-ligand surfaces to discover chemical inducers of proximity
James B. Shaum, Miquel Muñoz i Ordoño, Erica A. Steen, Daniela Vanessa Wenge, Hakyung Cheong, Jordan Janowski, Moritz Hunkeler, Eric M. Bilotta, Zoe J. Rutter, Paige A. Barta, Abby M. Thornhill, Natalia Milosevich, Lauren M. Hargis, Timothy R. Bishop, Trever R. Carter, , Michael A. Erb
This study uses high-throughput chemistry to discover chemical inducers of proximity by modifying pre-existing ligands and screening for degrader activity.
Nature Chemical Biology · Feb 16, 2026Peer-reviewedBiochemistry