Lauren M. Hargis

This study uses a chemical degradation system to show FOXA1 opens chromatin exclusively at its binding sites, activating or repressing transcription based on the chromatin environment.

This study uses high-throughput chemistry to discover chemical inducers of proximity by modifying pre-existing ligands and screening for degrader activity.

This study investigates the effects of ENL YEATS domain inhibitors in leukemia models, finding that suppression of ENL target genes is not sufficient to explain their anti-leukemia effects.

This paper develops PCIP-1, a PARP-based chemical inducer of proximity that rewires DNA repair by recruiting BET proteins to PARP2, showing synthetic lethality in cancer cells with homologous recombination deficiencies.

This study identifies covalent small molecules that bind FOXA1, altering its chromatin remodeling activity in prostate cancer cells.