SWI/SNF-Dependent Chromatin Remodelling Establishes Gene Regulatory Programs in Early Human Embryos and Blastoids
Sam Samuel Franciscus Allegonda van Knippenberg, Maria Tryfonos, Joke De Busscher, Elena Biondi, Mairim Alexandra Solís, Chloe Lorent, Océane Girard, Suresh Kumar Poovathingal, Marta Wojno, Sherif Khodeer, Jade De Clercq, Antonina Mikorska, Inge Smeers, Eva Wigerinck, Yara Meynen, , Vincent Pasque
This study shows that SWI/SNF chromatin remodellers are critical for lineage specification in human embryos and blastoids by regulating enhancer accessibility and transcription factor binding.
bioRxiv · Sep 25, 2026 · PreprintDevelopmental Biology