Maria Tryfonos

This study shows that SWI/SNF chromatin remodellers are critical for lineage specification in human embryos and blastoids by regulating enhancer accessibility and transcription factor binding.

The frequency of menstrual cycles with a suboptimal decidual reaction determines the recurrence risk of miscarriage.

The paper uses single cell ATAC-seq to study chromatin remodeling in human endometrium across the menstrual cycle, identifying dynamic chromatin regions and their role in implantation.

Endometrial assembloids of gland organoids and stromal cells reproduce midluteal cell states by scRNA-seq. Senescent decidual cells, tuned with dasatinib, track with whether co-cultured human blastocysts expand or stall.