Author

Chloe Lorent

KU LeuvenORCID 0009-0002-4044-3466Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1 Approach:deep learning· 1

Frequent Co-Authors

Ann SmeetsiD· 1 shared Antonina MikorskaiD· 1 shared Diether LambrechtsiD· 1 shared Edward W. GreeniD· 1 shared Elena BiondiiD· 1 shared Eva LioniD· 1 shared Eva WigerinckiD· 1 shared Evy Vanderheyden· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

Ann SmeetsORCID

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2 papers

Recent·Most cited

Functional Deorphanization of Tumor-reactive TCRs Uncovers a Landscape of Shared, Immune Dominant Antigens across Cancers

Orian Bricard, Razgar Seyed Rahmani, Frederik Peeters, Chloe Lorent, Thomas Van Brussel, Jieyi Xiong, Evy Vanderheyden, Rogier Schepers, Gino Philips, Eva Lion, Jiska van der Reest, Georg A. Halder, Ann Smeets, Michael Platten, Edward W. Green, , Diether Lambrechts

This study introduces TWISTAR, a platform to identify tumor-reactive TCRs and their antigens, revealing shared immunogenic targets across cancers and immune dominance.

bioRxiv · Oct 5, 2026 · PreprintCancer Biology

SWI/SNF-Dependent Chromatin Remodelling Establishes Gene Regulatory Programs in Early Human Embryos and Blastoids

Sam Samuel Franciscus Allegonda van Knippenberg, Maria Tryfonos, Joke De Busscher, Elena Biondi, Mairim Alexandra Solís, Chloe Lorent, Océane Girard, Suresh Kumar Poovathingal, Marta Wojno, Sherif Khodeer, Jade De Clercq, Antonina Mikorska, Inge Smeers, Eva Wigerinck, Yara Meynen, , Vincent Pasque

This study shows that SWI/SNF chromatin remodellers are critical for lineage specification in human embryos and blastoids by regulating enhancer accessibility and transcription factor binding.

bioRxiv · Sep 25, 2026 · PreprintDevelopmental Biology