CXCL13/CXCR5 Chemokine Axis Promotes CXCR5+CD19+ B-Cell and Follicular/Effector CXCR5+CD4+ T-Cell Responses in the Lungs Associated with Protection from Severe and Fatal COVID-19 Following Infection with Pathogenic SARS-CoV-2 Delta Variant
Hawa Vahed, Aziz Alami Chentoufi, Swayam Prakash, Afshana Quadiri, Sweta Karan, Yassir Lekhbach, Etinosa Omorogieva, Swena Patel, Jimmy Tadros, Emma Jane Liao, Lauren Lau, Delia F. Tifrea, Lbachir BenMohamed
This study shows that CXCL13 deficiency in mice worsens SARS-CoV-2 infection, with higher viral load, lung damage, and reduced B and T cell responses.
bioRxiv · Apr 18, 2025 · PreprintImmunology