Delia F. Tifrea

This study investigates how SARS-CoV-2 RNA and nucleocapsid-containing immune complexes drive inflammation and endothelial dysfunction through Fcγ receptor and TLR-8 pathways.

This study identifies a conserved CD74+ macrophage niche driven by MIF-CD74 signaling that supports multi-organ metastasis in breast cancer and shows its therapeutic targeting reduces metastatic burden.

This study shows that CXCL13 deficiency in mice worsens SARS-CoV-2 infection, with higher viral load, lung damage, and reduced B and T cell responses.

The paper isolates and characterizes two colorectal cancer stem cell subtypes, showing they create distinct tumor microenvironments and unify existing CRC classifications.

This paper develops a multi-antigen mRNA/LNP-based pan-CoV vaccine that provides cross-protective immunity against multiple SARS-CoV-2 variants in a hamster model.

This paper constructs a comprehensive spatially resolved single-cell genomic atlas of the adult human breast, identifying 11 major cell types and revealing diverse immune and epithelial cell populations.