GGCX promotes Eurasian avian-like H1N1 swine influenza virus adaption to interspecies receptor binding
Jiahui Zou, Meijun Jiang, Rong Xiao, Huimin Sun, Hailong Liu, Thomas P. Peacock, Shaoyu Tu, Tong Chen, Jin-Li Guo, Yaxin Zhao, William Barclay, Shengsong Xie, Hongbo Zhou
This study identifies GGCX as a key factor enabling EA H1N1 SIV adaptation to human-type -2,6 sialic acid receptors through HA carboxylation, suggesting it as a potential antiviral target.
Nature Communications · Jan 14, 2025Peer-reviewedMicrobiology