Loss of AKAP1 triggers Drp1 dephosphorylation-mediated mitochondrial fission and loss in retinal ganglion cells
Genea Edwards, Guy A Perkins, Keun-young Kim A, YeEun Kong, Yonghoon Lee, Soo‐Ho Choi, Yujia Liu, Dorota Skowronska‐Krawczyk, Robert Neal Weinreb, Linda M. Zangwill, Stefan Strack, Won‐Kyu Ju
This study shows that loss of AKAP1 leads to Drp1 dephosphorylation, mitochondrial fragmentation, and RGC dysfunction in glaucoma, suggesting AKAP1 as a therapeutic target.
Cell Death and Disease · Apr 20, 2020Peer-reviewedNeuroscience