Asynchronous excitatory neuron development in an isogenic cortical spheroid model of Down syndrome
Zhen Li, Jenny A. Klein, Sanjeev Rampam, Ronni Kurzion, Natalie Baker Campbell, Yesha Patel, Tarik F. Haydar, Ella Zeldich
This study uses isogenic cortical spheroids and scRNA-seq to identify transcriptomic changes in trisomic cells, revealing developmental asynchrony in excitatory neurons in Down syndrome.
Frontiers in Neuroscience · Sep 7, 2022Peer-reviewedNeuroscience