Natalie Baker Campbell

This study investigates how trisomy 21 affects oligodendrocyte development and neuron-glia communication in human forebrain assembloids, finding a shift toward a pre-myelinating state and disrupted myelination.

This paper introduces CLARI-O, a tissue-clearing technique for 3D visualization of cortical organoids and assembloids, enabling structural and functional analysis of cellular interactions and integration in vitro and in vivo.

This study shows that exposing oligodendrocyte-enriched cortical organoids to a specific medium during development enhances neuronal activity and maturation while preserving oligodendrocyte development.

This study uses isogenic cortical spheroids and scRNA-seq to identify transcriptomic changes in trisomic cells, revealing developmental asynchrony in excitatory neurons in Down syndrome.