Author

Yesu Addepalli

The University of Texas Southwestern Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Andrew S. LemoffiD· 1 shared Ann Marie FluschéiD· 1 shared Bingnan Wang· 1 shared Chiho KimiD· 1 shared Chuo CheniD· 1 shared Ilgen MenderiD· 1 shared Jerry W. ShayiD· 1 shared Lawrence LumiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Andrew S. LemoffORCID

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1 paper

Recent·Most cited

Targeting tankyrase scaffolding in the β-catenin destruction complex by PROTAC overcomes the limitation of catalytic inhibitors in cancer

Qian Wang, Liping Li, Lin You, Shuai Wang, Lei Han, Bingnan Wang, Liping Yao, Yesu Addepalli, Yong De Lu, Ilgen Mender, Ann Marie Flusché, Chiho Kim, Nageswari Yarravarapu, Andrew S. Lemoff, Lawrence Lum, , Chuo Chen

This study shows that degrading tankyrase (TNKS) with PROTACs overcomes the limitations of catalytic inhibitors by preventing AXIN puncta formation and enhancing WNT/β-catenin pathway suppression in colorectal cancer.

bioRxiv · Sep 22, 2025 · PreprintCancer Biology