Author

Lawrence Lum

The University of Texas Southwestern Medical CenterORCID 0000-0002-6119-0253Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:perturbation response prediction· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Andrew S. LemoffiD· 1 shared Ann Marie FluschéiD· 1 shared Bingnan Wang· 1 shared Chiho KimiD· 1 shared Chuo CheniD· 1 shared David H. MathewsiD· 1 shared Ilgen MenderiD· 1 shared James KimiD· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

Andrew S. LemoffORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintSep 22, 2025

Targeting tankyrase scaffolding in the β-catenin destruction complex by PROTAC overcomes the limitation of catalytic inhibitors in cancer

Qian Wang, Liping Li, Lin You…·Chuo Chen

This study shows that degrading tankyrase (TNKS) with PROTACs overcomes the limitations of catalytic inhibitors by preventing AXIN puncta formation and enhancing WNT/β-catenin pathway suppression in colorectal cancer.

1 citation

humanexperimental assay

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Molecular BiologyNature CommunicationsPeer-reviewedSep 6, 2019

CRISPR/Cas9-based mutagenesis frequently provokes on-target mRNA misregulation

Rubina Tuladhar, Yunku Yeu, John Tyler Piazza…·Lawrence Lum

This study shows that CRISPR/Cas9-induced INDELs can lead to mRNA misregulation by creating foreign mRNAs or proteins in about half of edited cell lines.

219 citationstop 1%

humanCRISPR screen

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