Cancer BiologybioRxivPreprint
Targeting tankyrase scaffolding in the β-catenin destruction complex by PROTAC overcomes the limitation of catalytic inhibitors in cancer
Qian Wang, Liping Li, Lin You…·Chuo Chen
This study shows that degrading tankyrase (TNKS) with PROTACs overcomes the limitations of catalytic inhibitors by preventing AXIN puncta formation and enhancing WNT/β-catenin pathway suppression in colorectal cancer.
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