Targeting protein glycosylation and cholesterol metabolism in chemoresistant pancreatic cancer
Yunguang Li, Shijie Tang, Huan Wang, Hongwen Zhu, Shiwei Guo, Yehan Zhang, Yurun Lu, Maoyuan Sun, Juan He, Yikai Li, Ying Zhang, Xiaohan Shi, Yuanxiang Miao, Chaoliang Zhong, Yiqin Zhu, , Dong Gao
This study identifies statins as effective in targeting chemoresistant pancreatic cancer by inhibiting cholesterol metabolism and protein glycosylation, showing clinical benefit in a phase 2 trial.
bioRxiv · Apr 13, 2025 · PreprintCancer Biology