Author

Shijie Tang

Chinese Academy of SciencesORCID 0000-0002-8022-0374Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Shijie Tang2 papers · Carnegie Mellon University

Biology Disciplines

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Cancer Biology· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Assay:organoid / primary culture· 1

Frequent Co-Authors

Luonan CheniD· 3 shared Chaoliang Zhong· 2 shared Dong GaoiD· 2 shared Shiwei GuoiD· 2 shared Xiaohan ShiiD· 2 shared Yikai Li· 2 shared Yunguang LiiD· 2 shared Gang JiniD· 1 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersCancer Biology

Luonan ChenORCID

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3 papers

Recent·Most cited

ODFormer: a Virtual Organoid for Predicting Personalized Therapeutic Responses in Pancreatic Cancer

Jing Xu, Xiaolu Yang, Yunguang Li, Huang Wang, Yikai Li, Shijie Tang, Shiwei Guo, Jiawei Zou, Xiaohan Shi, Zexi Chen, Chaoliang Zhong, Penghao Li, Wei Jing, Kailian Zheng, Xinqian Wu, , Gang Jin

ODFormer predicts personalized drug responses in pancreatic cancer by simulating patient-derived organoids using transcriptomic and mutational data, outperforming existing methods and improving clinical outcomes.

bioRxiv · Jul 8, 2025 · PreprintBioinformatics

Targeting protein glycosylation and cholesterol metabolism in chemoresistant pancreatic cancer

Yunguang Li, Shijie Tang, Huan Wang, Hongwen Zhu, Shiwei Guo, Yehan Zhang, Yurun Lu, Maoyuan Sun, Juan He, Yikai Li, Ying Zhang, Xiaohan Shi, Yuanxiang Miao, Chaoliang Zhong, Yiqin Zhu, , Dong Gao

This study identifies statins as effective in targeting chemoresistant pancreatic cancer by inhibiting cholesterol metabolism and protein glycosylation, showing clinical benefit in a phase 2 trial.

bioRxiv · Apr 13, 2025 · PreprintCancer Biology

Concurrent PIK3CA mutant drives cachexia through inflammatory signaling in EGFR mutant lung cancer

Meiting Yue, Zhen Qin, Shijie Tang, Xinlei Cai, Yikai Zhao, Liang Chen, Luonan Chen, Hongbin Ji

This study identifies PIK3CA mutations as drivers of cachexia in EGFR-mutant lung cancer, showing that osimertinib can mitigate cachexia but chemotherapy fails, with aspirin offering a potential treatment.

bioRxiv · Jan 17, 2025 · PreprintCancer Biology