TRIM21 licenses pancreatic acinar fate by modulating BiP phase state through VCP-dependent retrotranslocation
Yifu Zhu, Ronghua Yu, Xue Luan, Yan Huang, 李权达, Yuran Zhao, Huixia Zhang, Xinghua Huang, Yuxin Chen, Xiaoya Wu, Zhongjun Zhao, Jingke Ding, Jing Xue, Chong Hong, Liye Ma, , Wenjie Ge
This study identifies TRIM21 as a regulator of BiP phase state under ER stress, preventing solidification and maintaining UPR function, with implications for pancreatic cancer.
bioRxiv · Oct 1, 2026 · PreprintCell Biology