Meng Wang

NR0B1 alters the 9-cis-retinoic acid response in Ewing Sarcoma cells

This study shows NR0B1 alters the 9-cis-retinoic acid response in Ewing Sarcoma cells by modulating nuclear receptor activity, suggesting NR0B1 inhibition could enhance retinoid therapy.

Differential Regulation of Large-scale Chromosome Conformations in Osteoblasts and Osteosarcoma

The paper uses CRISPR-Sirius to visualize differences in large-scale chromosome conformations between osteoblasts and osteosarcoma cells, revealing regulatory mechanisms involving H3K27me3 and CTCF/cohesin.

NQO1 phase condensation promotes stress granule assembly to facilitate pancreatic carcinogenesis

This study identifies NQO1's role in promoting stress granule assembly via phase separation to drive pancreatic carcinogenesis, independent of ROS.

Rhabdomyosarcoma fusion oncoprotein initially pioneers a neural signature in vivo

The paper identifies PAX3::FOXO1's pioneer function through partial/homeobox motif recognition and its role in initiating neural transcriptional programs in rhabdomyosarcoma.

Highly quantitative measurement of differential protein-genome binding with PerCell chromatin sequencing

The paper introduces a low-cost, flexible method for quantitative chromatin sequencing and enables cross-species epigenomic comparisons.

Fusion transcription factor dosage controls cell state in rhabdomyosarcoma

This study shows that varying levels of PAX3::FOXO1 protein affect cell state and epigenetic heterogeneity in rhabdomyosarcoma.

Epigenetic Regulation of Nuclear Lamina-Associated Heterochromatin by HAT1 and the Acetylation of Newly Synthesized Histones

This study shows HAT1 acetylates new histones during DNA replication, regulating chromatin state inheritance and nuclear lamina-heterochromatin interactions.

Pioneer activity of an oncogenic fusion transcription factor at inaccessible chromatin

This study investigates the chromatin-binding properties of the oncogenic PAX3-FOXO1 fusion protein using pc-ChIP-seq, revealing its pioneer function at repressed chromatin in RMS cells.

Distinct isoforms of Nrf1 diversely regulate different subsets of its cognate target genes

The paper investigates how different Nrf1 isoforms regulate distinct subsets of target genes, showing that Nrf1{gamma} acts as a dominant-negative competitor to Nrf1/{beta}.