Concurrent PIK3CA mutant drives cachexia through inflammatory signaling in EGFR mutant lung cancer
Meiting Yue, Zhen Qin, Shijie Tang, Xinlei Cai, Yikai Zhao, Liang Chen, Luonan Chen, Hongbin Ji
This study identifies PIK3CA mutations as drivers of cachexia in EGFR-mutant lung cancer, showing that osimertinib can mitigate cachexia but chemotherapy fails, with aspirin offering a potential treatment.
bioRxiv · Jan 17, 2025 · PreprintCancer Biology