Zhen Qin

METAHICT enables comprehensive genome-resolved microbiome analysis with metagenomic Hi-C

METAHICT improves metagenomic Hi-C analysis by integrating binning, reassembly, and downstream tools to recover high-quality MAGs and reduce contamination.

Langerhans Cells Drive Tfh and B Cell Responses Independent of Canonical Cytokine Signals

This study shows Langerhans cells drive Tfh and B cell responses without needing IL-6, type-I interferons, or ICOS-L, challenging the cytokine-centric model of T cell differentiation.

Concurrent PIK3CA mutant drives cachexia through inflammatory signaling in EGFR mutant lung cancer

This study identifies PIK3CA mutations as drivers of cachexia in EGFR-mutant lung cancer, showing that osimertinib can mitigate cachexia but chemotherapy fails, with aspirin offering a potential treatment.

Lysyl oxidase inhibition drives the transdifferentiation from lung adenocarcinoma to squamous cell carcinoma in mice

This study shows that lysyl oxidase inhibition in a mouse model drives lung adenocarcinoma to squamous cell carcinoma transdifferentiation, independent of LKB1 status.