A CRISPR-based genome-wide screen for adipogenesis reveals new insights into mitotic expansion and lipogenesis.
Rachel E. Turn, Keren I. Hilgendorf, Carl T. Johnson, Kyuho Han, Atefeh Rabiee, János Demeter, Mohammad Ovais Aziz‐Zanjani, Pablo Domizi, Ran Cheng, Yingdi Zhu, Zewen Jiang, Katrin J. Svensson, Michael Cory Bassik, Peter K. Jackson
The paper uses a CRISPR-based screen in 3T3-L1 cells to identify regulators of adipogenesis, finding that protein translation and stability mechanisms are critical for adipocyte expansion and lipogenesis.
bioRxiv · Jul 13, 2020 · PreprintMolecular Biology