Keren I. Hilgendorf

The paper identifies 9S-HODE, a lipid secreted by lean adipocytes, as a ferroptosis inducer that suppresses breast cancer while sparing normal cells, with therapeutic potential in obese mice.

This study shows that hyperlipidemia, not obesity alone, drives breast cancer growth in mice, suggesting lipid-lowering therapies could reduce cancer risk in obese individuals.

This study identifies ZAG/AZGP1 as a secreted factor from triple-negative breast cancer cells that promotes fibrosis in the tumor microenvironment and is linked to poor patient prognosis.

The paper uses a CRISPR-based screen in 3T3-L1 cells to identify regulators of adipogenesis, finding that protein translation and stability mechanisms are critical for adipocyte expansion and lipogenesis.