Targeting Endothelial PERK Accelerates Lymphoid Regeneration by Enhancing DLL4-NOTCH3 Signaling at the Pre-B Niche
Bingqing Zou, Qiuyun Chen, Junjun Zheng, Yimin Ma, Jay Myers, Yinghui Shang, Mofei Huang, Paul A. Christensen, Stanley Adoro, Chih-Hang Anthony Tang, Chih‐Chi Andrew Hu, Sai Ravi Pingali, Wei Xin, Keith Syson Chan, Stephen T.C. Wong, , Lan Zhou
This study identifies PERK activation in bone marrow endothelium as a regulator of DLL4-NOTCH3 signaling, which enhances lymphoid regeneration after transplantation.
bioRxiv · Oct 15, 2025 · PreprintCell Biology