Stephen T.C. Wong

CodeCytos: AI-assisted spatial molecular imaging analysis via code-augmented agent action space

CodeCytos improves spatial molecular imaging analysis by enabling dynamic, programmable interaction with tissue data, outperforming baseline approaches in custom feature exploration.

Targeting Endothelial PERK Accelerates Lymphoid Regeneration by Enhancing DLL4-NOTCH3 Signaling at the Pre-B Niche

This study identifies PERK activation in bone marrow endothelium as a regulator of DLL4-NOTCH3 signaling, which enhances lymphoid regeneration after transplantation.

Site-Specific Immune and Stromal Architecture Drive Resistance to Trastuzumab Deruxtecan in HER2+ Metastatic Breast Cancer

This study identifies immune and stromal factors driving resistance to Trastuzumab Deruxtecan in HER2+ metastatic breast cancer using spatial proteomics.

MUSTANG: MUlti-sample Spatial Transcriptomics data ANalysis with cross-sample transcriptional similarity Guidance

MUSTANG performs multi-sample spatial transcriptomics analysis by integrating cross-sample similarity and spatial correlation to improve cellular deconvolution.

Charting Single Cell Lineage Dynamics and Mutation Networks via Homing CRISPR

The paper introduces LINEMAP, a computational framework that traces and maps mutation networks in single-cell lineage dynamics using homing CRISPR technology.

Epithelial-Mesenchymal Plasticity is regulated by inflammatory signalling networks coupled to cell morphology.

The paper shows that epithelial-mesenchymal plasticity is regulated by inflammatory signalling networks linked to cell morphology through changes in microtubule and nuclear organization.