Keith Syson Chan

This study identifies ferrous iron accumulation as a hallmark of therapy-induced senescence and shows that ferroptosis induction can eliminate residual tumor cells.

UniST reconstructs dense 3D spatial transcriptomics data from sparse serial sections, restoring structural continuity and biologically meaningful expression patterns in multiple tissue contexts.

This study identifies PERK activation in bone marrow endothelium as a regulator of DLL4-NOTCH3 signaling, which enhances lymphoid regeneration after transplantation.

This study maps tumor evolution and microenvironment dynamics in colorectal cancer using spatial multi-omic data, identifying key genes associated with immune exclusion and prognosis.