Jian Wang

The paper introduces COMET, a lightweight head-mounted mesoscope for cortex-wide single-cell calcium imaging in freely moving mice, demonstrating its ability to capture neural activity during natural behaviors.

This study identifies IGF1R-dependent neutrophil reprogramming in the bone marrow microenvironment during prostate cancer metastasis and shows its therapeutic targeting potential.

This paper introduces an improved nanopore sequencing platform called CycloneSEQ, demonstrating long-duration sequencing and high yield with applications in genomics.

The paper constructs a high-resolution haplotype-resolved reference panel from the China Kadoorie Biobank study and demonstrates its superior performance in imputing microarray data compared to existing panels.

This study uses Mendelian randomization to identify causal relationships between gut microbiome composition and blood metabolites in a Chinese cohort.

This study identifies genetic loci associated with the oral microbiome using metagenome-genome-wide association studies in over 1,915 individuals.

The paper presents 545 silkworm genomes to explore genotype-phenotype relationships, identifying new genes and variants linked to domestication and adaptation.

This paper performs M-GWAS on a Chinese cohort to identify genetic contributions to the gut microbiome and its associations with complex diseases.

This study analyzes whole-genome sequencing data from 332 Chinese COVID-19 patients to identify genetic variants associated with disease severity and susceptibility.

The paper introduces a new sequencing chemistry (CoolMPS) that improves signal intensity and eliminates scar interference in massively parallel sequencing.

This study shows that Cdc42 is essential for lymphatic vessel branching, maturation, and valve formation during embryonic development.

This study identifies the Src/FAK complex as a regulator of cMyBP-C tyrosine phosphorylation in cardiac hypertrophy, showing their physical interaction and reciprocal regulation.

The paper presents a draft genome of Solanum aethiopicum, identifies expanded resistance and drought tolerance genes, and identifies SNPs linked to these traits for breeding applications.

The paper presents a chromosome-level genome of black rockfish, identifies candidate genes related to viviparity, and proposes a reproductive model.

This paper introduces stLFR, a low-cost method for long DNA sequencing that enables accurate variant calling, haplotyping, and de novo assembly.

The paper presents a single-cell transcriptomic analysis of nucleated cells in umbilical cord blood, identifying cell types, subpopulations, and transcriptional programs that may impact transplant outcomes.

This study identifies HLA-DQA1 as the major independent genetic risk for ACPA-positive RA in Han population through MHC region sequencing and HLA-typing.

This study shows that adding genetic screening to newborn hearing tests in China improves detection and reduces loss-to-follow-up, with significant benefits for identifying preventable hearing loss.

The paper evaluates index mis-assignment rates on DNB-based sequencing platforms and finds they are exceptionally low, suggesting reliable multiplex sequencing.

MetaPGN constructs and visualizes pangenome networks from microbial genomes or metagenomes, revealing genetic diversity in E. coli and gut microbiomes.