Glutamine-regulated VCP acetylation creates a proteostasis vulnerability in RB1-deficient tumor
Bing‐Hui Yang, Ying Cao, Yining Tao, Haoyu Wang, Haoru Dong, Xiyu Yang, Xin He, Bowen Zhao, Kaiyuan Liu, Zongyi Wang, Jiakang Shen, Yan Yan, Qi Zhang, Zhuoying Wang, Yu Bing Lv, , Wei Sun
This study identifies VCP inhibition as a therapeutic strategy for RB1-deficient tumors by revealing glutamine-regulated VCP acetylation as a proteostasis vulnerability.
bioRxiv · Sep 17, 2026 · PreprintCell Biology