The gp120 Envelope Glycoprotein of HIV-1 Triggers Macropinocytosis in Primary CD4+ T Cells to Promote HIV-1 Infection
Praveen Manivannan, Cristina Santos da Costa, Yipei Tang, Xinghao Wang, Joel A. Swanson, Tomoyuki Murakami, Akira Ono, Philip D. King
This study shows HIV-1 gp120 triggers macropinocytosis in CD4+ T cells, which facilitates HIV-1 infection through a calcium-independent phospholipase A2-dependent pathway.
bioRxiv · Apr 28, 2026 · PreprintMicrobiology