Akira Ono

The paper identifies a specific MA-SeCTCA tRNA interface in HIV-1 Gag that enhances virion infectivity and replication.

This study shows HIV-1 gp120 triggers macropinocytosis in CD4+ T cells, which facilitates HIV-1 infection through a calcium-independent phospholipase A2-dependent pathway.

This paper shows that M-Sec promotes HIV-1 production by facilitating Gag puncta formation and Env incorporation through PIP2, Ral, and the exocyst complex.

This study shows HIV-1 enters primary CD4+ T cells via macropinocytosis, a process that can be inhibited to block viral entry and infection.

The paper shows that PIP2 facilitates the incorporation of CD43, PSGL-1, and CD44 into HIV-1 particles by promoting their co-clustering with Gag at the plasma membrane.

This study identifies M-Sec as a regulator of CSF-1 receptor activation by promoting Fms aggregate formation through PIP2 binding.