Philip D. King

This study shows HIV-1 gp120 triggers macropinocytosis in CD4+ T cells, which facilitates HIV-1 infection through a calcium-independent phospholipase A2-dependent pathway.

This study shows HIV-1 enters primary CD4+ T cells via macropinocytosis, a process that can be inhibited to block viral entry and infection.

This study shows the C2 domain enhances Ras GTPase activating protein catalytic activity by interacting with the Ras allosteric lobe, as demonstrated through structural analysis and mutation studies in mice and SynGAP.

The paper identifies genetic variants in RASA1 and EPHB4 associated with vein of Galen malformations through exome analysis and single-cell transcriptomics.

This study shows that RASA1 is required for the development of lymphovenous and venous valves by regulating collagen IV export from endothelial cells in mice.