Macropinosomes are a site of HIV-1 entry into primary CD4+ T cells
Tomoyuki Murakami, Ricardo de Souza Cardoso, Praveen Manivannan, Ya-Ting Chang, Eric C. Rentchler, Kai-Neng Chou, Yipei Tang, Joel A. Swanson, Philip D. King, Akira Ono
This study shows HIV-1 enters primary CD4+ T cells via macropinocytosis, a process that can be inhibited to block viral entry and infection.
Proceedings of the National Academy of Sciences · Jun 4, 2025Peer-reviewedMicrobiology