A U1-U3 snRNA-snoRNA interaction couples SF3B1 mutation to chromatin-state rewiring and genome instability
Peng Xia, Han Li, Yiyi Ji, Cheng‐Wei Ju, Yiqian Pan, Jing Mo, Xuanhao Zhu, Lijie Zhao, Ruitu Lyu, Erica L. Niewold, Mike Fernandez, Yuxi Ai, Jiangbo Wei, Robert K. Bradley, Lili Wang, , Chuan He
This paper identifies a U1-U3 snRNA-snoRNA interaction that links SF3B1 mutations to chromatin-state changes and genome instability, with therapeutic potential through antisense oligonucleotides.
bioRxiv · Jun 8, 2026 · PreprintCell Biology